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Hormones

The INSULIN hormone : dosage and side effects

 

 

 

Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-times injections, insulin will help to bring glycogen and other nutrients to the muscle.

 

With no doubt, the administration of insulin has caused considerable changes in professional bodybuilding. Nowadays many sportsmen take the insulin concomitant with the growing hormone, steroids, the Clenbuterol, the triodes hormones and/or IGF-1. In this kind of combination the insulin can be even more efficient and bring the rack that the growing hormone and IGF-1 to become strong constructors of muscle and factors in the intense process of burning the fatness”. (Quote by B.H. Phillips)In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer period and can put the user in an unexpected state of hypoglycemia.

The name has it origin in Latin: “island”, because the active cells of the pancreas that secrets them are call the Langerghans Island (the pancreatic island). A healthy organism produces in 24 hours 1.6mg of insulin. If there are diseases in process ,the results is an insufficient secretion of insulin (diabetes type 1, insulin-dependent) or the insulin that is secreted doesn’t exercises his action because of the inefficiency of the receptors (diabetes type 2, insulin-resistant). The insulin bring the proteins (aminoacides) and the glucide (glucose, the sugar in blood) to the place where they will be used. Next, the insulin bring the glucose into the cells, where it serves as a source of energy or can be conserved, and the aminoacides are moved where the synthesis of the protein takes place.

The insulin hormone also helps the muscle cells to assimilate the glucose and aminoacides that helps the anabolic processes. Through those it is avoided the destruction of the muscle tissue, so the insulin is an anti-catabolic hormone. In a bigger measure  the process of glycogen accumulation  in the muscle and liver depend of this hormone. The brain also are relatively “dependet” by insulin, but it has an indirect action for their metabolism. The insulin intensifyes the anabolic state  in the adipose tissue leading to the accumulation of fat by the way to improve the synthesis and transport of the fat acids. There are accessible on the market all three types of insulin: the standard, the pure and the human one. The standard and pure products are different by the grad of purification and by quantity of the an-insulin additives. Nowadays, the standard product is about to be excluded from the medical product nomenclature.

Both products can be obtained by different sources: from beast, pigs or can be mix. The most similar to human insulin is the pig insulin- they differ by 2 rests of amino acids in the circle. Lately, with the help of genetic engineering it was obtained microorganisms apt to produce several hormones. The products obtained this way are called recombined. The activity of the product is measured in activity units (in international system UI). 1UI= the activity of .04082mg of crystal insulin. All types of insulin must be kept at cold, in the fridge but not in freezer.

There are two principal types of insulin: with long action and short action. The short time action insulin begin to action after 15-20 minutes after the injection, and the maximal effect approximately after 2 hours, the substance remain in the body for approximately 6 hours period. The long time action insulin usually starts to action after 1-2 hours after the injection, and has effect  up to 10-36 hours.

Side effects of insulin administration :

If it is injected a pretty big dose of synthetic insulin it takes place a decrease at the level of sugar in the body- so , it begin the hypo-glicemic faze, that is characterized by total weakness, foot trembling, leak of concentration, excessive sweat. That may have as an effect the loss of conscience that can lead to coma. The research proven that in case of correct administration of the insulin, combined with others hormones, it improves the change of energy at it accelerates it reestablish, it is increased the capacity of assimilation of food and the appetite. On the shape of the moderated hypo-glicemic, in the human body takes place a defensive reaction- the intensify in secretion of the growing hormone. In some cases the  level can increase up to 5-7 times compare with the normal level. The use of anabolic steroids intensify the action of synthetic insulin: it is intensifyed the matrices protein synthesis, ADN and ARN. It is accelerated the action of pentophosphatyc cycle, where the synthesis of the protein happens.

There are known two ways of administrating the insulin with an anabolizant purpose:

the firs way: the insulin is injected on empty stomach, when hypo-glicemia appears- it is waited 30—60 minutes then the food is served. The receive of the food stops  hypo-glicemia.  30-60 minutes break is necessary to obtain the maximal secretion effect of the growing hormone. The excessive secretion of the growing hormone happens not only as a reaction to the decrease of the blood sugar  but also a reaction  of the amino acids  concentration decreasing.


second way: first it is served the meal, then the injection of the insulin, for a better assimilation of the food. The first way is a more efficient one, because it allows to obtain a more intense anabolic effect, but it is more risky, because some people tend to have hypo-glicemia even after injecting small doses of insulin. This risk can be excluded if it is administrated on empty stomach a dose not bigger then 2 UI of insulin. The second way is safer because the injection with insulin after the meal doesn’t cause a hypo-glicemic reaction it only “opens” the cells membranes ditches, allowing the access of the nutritive substance, intensify the syntheses processes in the organism. The anabolic action of the insulin in the second way of administration is weaker. In both cases, the action of the insulin is at least 6 hours.


In this time can appear repeated states of hypo-glicemia, this is why you must always have food at your disposition to stop the state of hypo-glicemia, till the insulin action is stopped. It is necessary to learn how to vary the consume of glucides so that it is felt a hypo-glicemia but without the risk of reaching a hypo-glicemic coma. It is recommended the consume of glucides, with a small glicemic index, in combination with a combination of glucid-protein of mega-gainer type. It is recommended the exclusion of products that are saturated with fat acids. The diet must contain a sufficient quantity of complete proteins (no less then 2.5gr/ kg of corporal weight), vitamins. It is also recommended that in the period of administration at least 20 minutes/ day of aerobic exercises.

The last variant in very risking and it is used only by the advanced athletes. According to I. Bulanov, the administration of insulin must start with 4 UI-in the first day and then add 4 UI at every day till it is reached the level of 20 UI and then maintain this dose. Most sportive use the insulin in clinical way even though many of them don’t do the same with steroids. For example a sportive takes insulin for a period of 8 weeks, and then in the next 8 weeks stops the administration. It is considered that this method can decrease the negative aspects on a long period of administration of the insulin, inclusive the reduction of the ability of the body to send neurotic’s impulse to signal the decrease of the level of sugar in the body. The utilization of insulin for competitions is much known among the professions and the advanced amateurs. One of the most complicated things for a sportive that participates to competitions is the “fill” with glucides at the right time. The bodybuilders with experience say that the fill with glucides, combined with the administration of insulin leads to incredible results and increases the possibility to reach a maximum level of  muscle volume and  density.

The use of synthetic insulin leads to a strong synthesis of the adipose tissue of the body. This is explained by the fact that the overcome of insulin, correlated with a not equilibrated diet, with many glucides, activates some enzymes. That transforms the glucose into glycerol, which is deposed in the fat section. To stop the formation and depositing the fats, the performance trainee when practicing insulin-therapy, use a strong combination to burn the fatness that is formed by the Thyroidtironina (T3) and Clenbuterol. The  medicine specialists that study this problem recommend in these cases to administrate the Thyroidtironina, because of the combined action of the steroids with the insulin decreases the function of tiroide gland. Another factor of burning the fatness is the inclusion in the cycle of the growing hormone, because beside the pronounced anabolic action over the muscles it also has a strong lipotropic action .

Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.

 

Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.

Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during this slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting.

 

 

Insulin use cannot be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences.

 

 

 

 

 

 

Comments  

 
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