The schoolars named this polypeptide Insulin as Growth Factor–1 – IGF–1. It represents a chain of 67 amino acids that have a similar structural shape as the promulgator one of the insulin. It is said that the IGF-1 not only doe it copy’s the anabolic and anti-catabolic qualities but it also accentuate them. After it was known, the IGF-1 is stimulated by the growing hormone, so the anabolic effect of this hormone can be attributed not to the hormone but to the IGF-1.
The supplementary researches showed that the synthesis of the IGF-1 is directly connected with a high alimentary diet, rich in proteins and calories. The restrictive diets reduce the secretion of the IGF-1 after 24 hours from the beginning of the diet and the secretion decreases with 10-15% over the next 7-10 days. The decreasing of the level of IGF-1in the blood till the minimum leads to a loss of azoth in the body and as a result the distraction of muscle tissue.
In a test, a group experimental of women with a normal weight had meals very often and in big quantities- the final results showed that the level of IGF-1 in the blood increased with 19%!
This example is not an argument for the excessive eating because the secretion of IGF-1 is in indirect relation with the quantity of fatness from the adipose tissue. The obesity excludes the possibility of an intense production of IGF-1. In the faze of preparation for the competitions the caloric level of the alimentary diet must not be decreased from the proteins.
The specific quantity of proteins in the alimentation must be maintained or increased, in contrary, the insufficiency of the amino acids will lead to a decrease at the level of IGF-1 and next, to catabolic muscle tissue.
GH and IGF-1:
Perhaps the most relevant effect of IGF-1 is the ability of IGF-1 to increase protein synthesis by
increasing cellular mRNA formation (mRNA makes protein) as well as increasing uptake of amino
acids. This effect on protein synthesis can lead to increased lean mass.
The research indicates that this
effect is dependent on GH presence as well. So IGF-1 alone does not promote such effects. Nor does
GH. It appears the combination of the two most consistently lead to increased protein synthesis.
GH and IGF-1 are negative regulators of GH release so an increase in either (from a GH injection)
reduces the secretion of GH. IGF-1 is very difficult to obtain in a useable condition.... it must be handled
very gently and have bee kept at a rather precise temperature at all times. One can stimulate IGF
production through the use of an oral steroid during cycle. Dbol, for example, causes a rather extensive release of IGF during the first pass through the liver.
The leading studies in this area: (Ney, 1999, Yarasheski, 1994.... Am J. App. Phys.) In the Yarasheski study, no increase in lean muscle mass was noticed in the subjects using GH alone, but significant gains were found in subjects that supplemented with IGF and GH...add in the steroids and look out! Yarasheski studied weight trained athletes, supplementing one group with GH alone, and one group with GH and IGF. "So IGF-1 alone does not promote such effects. (Leanness and increased lean mass) Nor does GH.
It appears the combination of the two most consistently lead to increased protein synthesis." Both seem to negatively downregulate the other over time, so as to lead to diminishing returns. Cycling would be in order for that reason. Also supplementing both is necessary because one or the other alone will suppress the natural production of the non-supplemented Latest study by Yarashevski - with GH alone...8 to 12% change in lean body composition. 6% increase in muscle mass.
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